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Objective@#To explore the preoperative anxiety and health information literacy of patients undergoing percutaneous coronary intervention (PCI), and to analyze the correlation between them, so as to provide reference for promoting psychological care of patients.@*Methods@#A total of 221 PCI patients treated in our hospital were selected by convenience sampling, and the preoperative anxiety questionnaire and health information literacy questionnaire were used to investigate.@*Results@#The score of health information literacy of PCI patients was (93.38±11.11) points. The score of information morality was the highest (79.1%) and the score of information acquisition and cognition was the lowest (59.3% and 59.9%). The score of anxiety was (27.07±3.96) points before operation, among them, uncertainty score was the highest with (9.73±1.47) points. The scores of all dimensions of health information literacy were negatively correlated with preoperative anxiety scores (r=-0.354~-0.133, P<0.05).@*Conclusions@#The preoperative anxiety level of PCI patients is relatively high, the higher the health information literacy level of patients, the lower the preoperative anxiety. Nurses should pay attention to improve the health information literacy of patients, reduce preoperative anxiety to improve the outcome of patients.
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Objective To explore the preoperative anxiety and health information literacy of patients undergoing percutaneous coronary intervention (PCI), and to analyze the correlation between them, so as to provide reference for promoting psychological care of patients. Methods A total of 221 PCI patients treated in our hospital were selected by convenience sampling, and the preoperative anxiety questionnaire and health information literacy questionnaire were used to investigate. Results The score of health information literacy of PCI patients was (93.38±11.11) points. The score of information morality was the highest (79.1%) and the score of information acquisition and cognition was the lowest (59.3% and 59.9%). The score of anxiety was (27.07±3.96) points before operation, among them, uncertainty score was the highest with (9.73 ± 1.47) points. The scores of all dimensions of health information literacy were negatively correlated with preoperative anxiety scores (r=-0.354~-0.133, P<0.05). Conclusions The preoperative anxiety level of PCI patients is relatively high, the higher the health information literacy level of patients, the lower the preoperative anxiety. Nurses should pay attention to improve the health information literacy of patients, reduce preoperative anxiety to improve the outcome of patients.
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Objective To investigate the health information literacy (HIL) conditions of patients after percutaneous coronary intervention (PCI) operation and to discuss the influence of HIL on the nursing knowledge acquisition behavior of the patients. Methods A total of 230 postoperative PCI patients who accepted treatment in Cardiology Department of our hospital were selected. General information questionnaire, 2012 National Residents Health Literacy Supervision Investigation Questionnaire-HIL part and nursing knowledge acquisition behavior questionnaire were adopted. Results In this investigation, 230 questionnaires were recovered and 216 of them were effective. HIL level of PCI postoperative patients was 24.1％ (52/216). Differences in HIL levels of patients of different ages, residential areas and educational degrees were of statistical significance (χ2=10.577, 12.657, 37.693, P<0.05). The scores of PCI postoperative exercise method and item analysis of PCI therapy institution and nursing knowledge obtained from medical care personnel, books, Internet and speeches in patients with HIL were 3.40±0.85, 3.35 ± 0.71, 3.37 ± 0.82, 3.75 ± 0.74, 3.54 ± 0.75 and 3.71 ± 0.82. They were significantly higher than the scores of 2.38±0.71, 2.40±0.76, 2.34±0.71, 2.48±0.75, 2.45±0.72 and 2.43±0.78 in the non HIL patients (t=6.657-9.000, P<0.05). The scores of nursing knowledge in coronary heart disease symptoms, PCI postoperative complications and aetiological agent of coronary heart disease,nursing knowledge sources of newspapers, TV and radio, relatives, and nursing knowledge acquisition barriers due to low educational level, incomprehension of terminology and lack of Internet knowledge of the patients with HIL were 2.37± 0.82, 2.63 ± 0.89, 2.42 ± 0.82, 2.37 ± 0.79, 2.50 ± 0.67, 2.48 ± 0.67, 2.46 ± 0.64, 2.46 ± 0.85, 2.54 ± 0.87 and 2.63±0.69. They were significantly lower than the scores of 3.43±0.78, 3.38±0.76, 3.45±0.74, 3.49±0.77, 3.32 ± 0.81, 3.41 ± 0.77 and 3.34 ± 0.83, 3.46 ± 0.70, 3.43 ± 0.74 and 3.41 ± 0.75 in the non HIL patients (t=-5.657-4.690, P<0.05). Conclusions HIL level of PCI postoperative patients is low, and patients in different HIL levels have different nursing knowledge acquisition behaviors.
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Objective To investigate the degradation of dicalcium phosphate dehydrate-coated Mg-Zn alloy in vivo and bone formation. Methods Left femoral condyles were drilled in 72 New Zealand rabbits, and were randomly divided into experiment group (n＝24, implanted with dicalcium phosphate dehydrate-coated Mg-Zn alloy rods), Mg-Zn alloy control group (n＝24, implanted with Mg-Zn alloy rods) and poly-L-lactide acid rod group (n＝24, implanted with poly-L-lactide acid rods). Serum concentrations of Mg~(2+) were examined 1 d pre-operation, and 1 d, 1 week, 2 weeks, 5 weeks and 10 weeks post-operation in experiment group and Mg-Zn alloy control group. Operation sites were examined by X-rays at 3, 6, 12 and 18 weeks post-operation. After X-ray examination at each time point, 6 rabbits in each group were sacrificed, and subjected to histopathological observation of live and kidney tissues by HE staining. Tissues from condyles of femur were observed by HE staining and 2, 4, 6-trinitrophenol rosein staining, and mineral apposition rate of bone was calculated. Results There was no significant difference in the concentrations of serum Mg~(2+) at each time point between Mg-Zn alloy control group and experiment group (P>0.05). X-ray examination revealed gas emerged near the implants 3 weeks after surgery in Mg-Zn alloy control group. However, there was no obvious histological abnormality in liver and kidney tissues. The mineral apposition rate was higher and the degradation of material was lower in experiment group than those in the other two groups. Conclusion Dicalcium phosphate dehydrate-coated Mg-Zn alloy has a favourable biocompatibility, and degrades more slowly in vivo.
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BACKGROUND:A novel biodegradable Mg-Zn alloy has been designed,in which the density and the Young's modulus are proximal to human bone,at the same time,it depletes the toxicity of aluminium and rare earth element in commercial magnesium alloys.OBJECTIVE:To evaluate the cytocompatibility of biodegradable Mg-Zn alloy.DESIGN,TIME AND SETTING:Contrast study was performed in the central laboratory of the Sixth People's Hospital of Shanghai Jiao Tong University between November 2007 and March 2008.MATERIALS:The Mg-6wt%Zn was prepared by School of Materials Science and Engineering of Shanghai Jiao Tong University,with the density was 1.82 g/cm3 and the Young's modulus was 44 GPa.L-929 cells for cytocompatibility test were provided by Chinese Academy of Science Type Culture Collection.Ten male New Zealand rabbits were employed in the hemolysis test.METHODS:The Mg-Zn alloy extraction medium was prepared by serial dilutions with fresh medium to 10%,50% and 100%.The experiments were carried out in a 96-well tissue-culture plate.Simple DMEM culture solution was taken as negative controls,while DMEM culture solution supplemented with 0.64% phenol served as positive controls.MAIN OUTCOME MEASURES:Relative proliferation rate of L-929 cells was determined at 2,4 and 7 days with MTT assay.The cytotoxicity of Mg-Zn alloy was evaluated according to ISO 10993-5:1999.The L-929 cell morphology and growth at 2,4 and 7 days were determined under inverted microscope.Based on ISO 10993-4:2002,hemolysis in vitro was evaluated through measuring erythrocyte lysis and ferrohemoglobin freeing degree with indirect contact method.RESULTS:The number of L-929 cells increased significantly and the morphology was not changed.The growth and morphology of cells in different Mg-Zn extraction medium had no difference from negative control group.Cytotoxicity test showed that biodegradable Mg-Zn alloy did not have obvious toxicity on L-929 cells,and the cytotoxicity of these extracts was in grade 0-1.Hemolysis test suggested that the Mg-Zn alloys did not have obvious hemolysis reaction,and the hemolysis index was 3.4%,which was less than the national standard (5%).CONCLUSION:The Mg-Zn alloys do not have obvious cytotoxicity and hemolysis reaction,which demonstrate that Mg-Zn alloys have good cytocompatibility.